Based on the seismic profile, analogue modeling and discrete element modeling method were carried out to study the deep genetic mechanism of the gravity instability structure and evolution process of the salt diapirs in the contractional zone of central Lower Congo Basin in the passive continental margin of Angola in West Africa. The effect of salt diapir activity on the migration of the sedimentary center of the mini-basin between the diapirs was further studied. The results show that the evolution process of salt diapirs in the contractional domain of central Lower Congo Basin is related to the stress conditions. In the early stage, it was mainly controlled by the effect of gravity spreading, and in the later stage, it was controlled by the effect of squeezing. According to the comparison between the results of analogue modeling and discrete element modeling and the seismic sections, the evolution process of salt diapir can be divided into the following three stages: 1) The early stage, the extended reactive diapir stage; 2) The mid stage, the passive diapir stage; 3) The late stage, squeezed active diapir stage. The sedimentary center of the mini-basin between the salt diapirs migrated to the diapirs with strong activities during the same period.